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Subsequent Malignant Neoplasms in Retinoblastoma Survivors

10 Mar 2021

Abstract excerpt

Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The...

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PMID: 33801943
DOI: 10.3390/cancers13061200

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