Article
Danish retinoblastoma patients 1943-2013 - genetic testing and clinical implications.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2016
Gregersen Pernille A, Urbak Steen F, Funding Mikkel, Overgaard Jens, Jensen Uffe B, Alsner Jan
Abstract excerpt
BACKGROUND: In heritable retinoblastoma there is a 50% risk of transmitting the RB1 mutation, and offspring carriers have more than 90% risk of developing retinoblastoma. Today, all newly diagnosed retinoblastoma patients in Denmark are screened for mutations in RB1, as opposed to only a minority of patients diagnosed before DNA testing was offered. Knowledge of heredity increases the chance of early diagnosis in...
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