Article
Mutation risk associated with paternal and maternal age in a cohort of retinoblastoma survivors.
Human genetics - 1 Jul 2012
Mills Melissa B, Hudgins Louanne, Balise Raymond R, Abramson David H, Kleinerman Ruth A
Abstract excerpt
Autosomal dominant conditions are known to be associated with advanced paternal age, and it has been suggested that retinoblastoma (Rb) also exhibits a paternal age effect due to the paternal origin of most new germline RB1 mutations. To further our understanding of the association of parental age and risk of de novo germline RB1 mutations, we evaluated the effect of parental age in a cohort of Rb survivors in...
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