Article
Correlation between Family RB1 Gene Pathogenic Variant with Clinical Features and Prognosis of Retinoblastoma under 5 Years Old.
Disease markers - 1 Jan 2021
Zhang Yi, Wang Yizhuo, Huang Dongsheng, Ma Jianmin, Zhang Weiling, Gu Huali, Zhou Yan, Yi You, Zhang Pinwei
Abstract excerpt
Retinoblastoma (RB) is the most common primary intraocular malignant tumor in infants and the prototype of human hereditary tumors. Its occurrence and development are closely related to the pathogenic variant of tumor suppressor RB1 gene. We aim to analyze the characteristics of RB1 gene pathogenic variant and clinical phenotype in retinoblastoma patients and their relatives. Children with RB were recruited from...
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