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Article

Impact of RB1 gene mutation type in retinoblastoma patients on clinical presentation and management outcome

23 Mar 2020

Abstract excerpt

OBJECTIVE/BACKGROUND: Retinoblastoma (RB), the most common intraocular malignancy in children, is caused by biallelic inactivation of the human retinoblastoma susceptibility gene (RB1). We are evaluating the impact of the type of RB1 gene mutation on clinical presentation and management outcome. METHODS: A retrospective case series of 50 patients with RB. Main outcomes were clinical and pathologic features and...

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Identifiers

PMID: 32222358
DOI: 10.1016/j.hemonc.2020.02.006

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