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Cooperative Hedgehog-EGFR signaling

26 Oct 2011

Abstract excerpt

It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy. The identification and characterization of cooperative cancer signaling pathways amenable to medical therapy is therefore a crucial...

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PMID: 22201734
DOI: 10.2741/3917

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