Article
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Nature reviews. Drug discovery - 1 Dec 2005
Hennessy Bryan T, Smith Debra L, Ram Prahlad T, Lu Yiling, Mills Gordon B
Abstract excerpt
Evolving studies with several different targeted therapeutic agents are demonstrating that patients with genomic alterations of the target, including amplification, translocation and mutation, are more likely to respond to the therapy. Recent studies indicate that numerous components of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway are targeted by amplification, mutation and translocation more frequently...
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