Article
Overexpressed HER2 in NSCLC is a possible therapeutic target of EGFR inhibitors.
Anticancer research - 1 Dec 2011
Ise Nobuyuki, Omi Kazuya, Nambara Daisuke, Higashiyama Shigeki, Goishi Katsutoshi
Abstract excerpt
BACKGROUND: "Oncogene addiction" is a concept in which tumor cells exhibit dependence on certain oncogene(s) for their sustained proliferation and survival, thus providing the rationale for molecular targeted therapies. Cancer cells addicted to epidermal growth factor receptor (EGFR) bear activated mutations in the EGFR gene, and these mutations are used as the markers for predicting carcinomas susceptible to...
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