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Article

EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects.

Cancer treatment reviews - 1 Aug 2012

Soria Jean-Charles, Mok Tony S, Cappuzzo Federico, Jänne Pasi A

Abstract excerpt

Non-small cell lung cancer (NSCLC) tumours with certain mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase have been termed 'oncogene addicted' to reflect their dependence on EGFR-mediated pro-survival signalling and their high susceptibility to apoptosis induced by EGFR tyrosine kinase inhibitors (EGFR-TKIs, e.g. gefitinib and erlotinib). The most common mutations (L858R and exon 19...

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Source

Identifiers

PMID: 22119437
DOI: 10.1016/j.ctrv.2011.10.003

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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