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Article

Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Immunity - 23 Dec 2011

Wendland Meike, Willenzon Stefanie, Kocks Jessica, Davalos-Misslitz Ana Clara, Hammerschmidt Swantje I, Schumann Kathrin, Kremmer Elisabeth, Sixt Michael, Hoffmeyer Angelika, Pabst Oliver, Förster Reinhold

Abstract excerpt

Little is known about mechanisms determining the homeostasis of lymphocytes within lymphoid organs. Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, we now show that semimature steady state dendritic cells (sDCs) constitutively trafficking into lymph nodes (LNs) were essential contributors to T cell homeostasis in these organs. sDCs provided vascular endothelial growth...

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Share to Lymph Nodes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22195748
DOI: 10.1016/j.immuni.2011.10.017

Genes

CCL21
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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