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An analysis of the function and expression of D6 on lymphatic endothelial cells

12 Mar 2013

Abstract excerpt

The mechanisms by which CC chemokine receptor (CCR)7 ligands are selectively presented on lymphatic endothelium in the presence of inflammatory chemokines are poorly understood. The chemokine-scavenging receptor D6 is expressed on lymphatic endothelial cells (LEC) and contributes to selective presentation of CCR7 ligands by suppressing inflammatory chemokine binding to LEC surfaces. As well as preventing...

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PMID: 23479571
DOI: 10.1182/blood-2012-04-425314

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