Article
Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry.
PloS one - 1 Jan 2011
Sweiss Nadera J, Zhang Wei, Franek Beverly S, Kariuki Silvia N, Moller David R, Patterson Karen C, Bennett Peggy, Girijala Lakshmi R, Nair Vaisak, Baughman Robert P, Garcia Joe G N, Niewold Timothy B
Abstract excerpt
BACKGROUND: Both type I interferon (IFN), also known as IFN-α and tumor necrosis factor alpha (TNF-α) have been implicated in the pathogenesis of sarcoidosis. We investigated serum levels of these cytokines in a large multi-ancestral sarcoidosis population to determine correlations between cytokine levels and disease phenotypes. METHODS: We studied serum samples from 98 patients with sarcoidosis, including 71...
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