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Article

A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys.

Journal of virology - 1 Jan 2011

Devaux Patricia, Hudacek Andrew W, Hodge Gregory, Reyes-Del Valle Jorge, McChesney Michael B, Cattaneo Roberto

Abstract excerpt

Measles remains a leading cause of death worldwide among children because it suppresses immune function. The measles virus (MV) P gene encodes three proteins (P, V, and C) that interfere with innate immunity, controlling STAT1, STAT2, mda5, and perhaps other key regulators of immune function. We identified here three residues in the shared domain of the P and V proteins-tyrosine 110, valine 112, and histidine...

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Source

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Identifiers

PMID: 20980517
DOI: 10.1128/JVI.00802-10
PMCID: PMC3014164

Genes

STAT1
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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