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Article

Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2012

Mimae Takahiro, Okada Morihito, Hagiyama Man, Miyata Yoshihiro, Tsutani Yasuhiro, Inoue Takao, Murakami Yoshinori, Ito Akihiko

Abstract excerpt

PURPOSE: Lung adenocarcinoma often manifests as tumors with mainly lepidic growth. The size of invasive foci determines a diagnosis of in situ, minimally invasive adenocarcinoma, or invasive types and suggests that some adenocarcinomas undergo malignant progression in that order. This study investigates how transcriptional aberrations in adenocarcinoma cells at the early stage define the clinical phenotypes of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22190591
DOI: 10.1158/1078-0432.CCR-11-1946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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