Article

Integrative Network Analysis of Early-Stage Lung Adenocarcinoma Identifies Aurora Kinase Inhibition as Interceptor of Invasion and Progression

2021-04-13

Abstract excerpt

<title>Abstract</title> <p>We present a gene signature distinguishing invasive and indolent tumors among early-stage lung adenocarcinoma (esLUAD). An Invasiveness Score estimated using the gene signature was strongly associated with survival of esLUAD patients in multiple independent cohorts and with the invasiveness phenotype in lung cancer cell lines. Regulatory network analysis identified aurora kinase as one...

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Literature Corpus work: d4c364f2-4755-5088-a00f-e269cef5528d
DOI: 10.21203/rs.3.rs-334210/v1

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