Article
Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis.
The American journal of surgical pathology - 1 Feb 2013
Onozato Maristela L, Kovach Alexandra E, Yeap Beow Y, Morales-Oyarvide Vicente, Klepeis Veronica E, Tammireddy Swathi, Heist Rebecca S, Mark Eugene J, Dias-Santagata Dora, Iafrate A John, Yagi Yukako, Mino-Kenudson Mari
Abstract excerpt
Tumor islands-large collections of tumor cells isolated within alveolar spaces-can be seen in lung adenocarcinomas. Recently we observed by 3-dimensional reconstruction that these structures were connected with each other and with the main tumor in different tissue planes, raising the possibility of tumor islands being a means of extension. However, the clinical and prognostic significance of tumor islands...
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