Flat Cell Variant of Lung Adenocarcinoma In Situ.

doi:10.1016/j.modpat.2025.100876

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Article

Flat Cell Variant of Lung Adenocarcinoma In Situ.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2025

Oka Naoyuki, Kishikawa Satsuki, Kashima Jumpei, Watanabe Hirokazu, Kusumoto Masahiko, Asakura Keisuke, Watanabe Shun-Ichi, Yatabe Yasushi

Abstract excerpt

Adenocarcinoma in situ (AIS) of the lungs has been increasingly diagnosed worldwide following the establishment of its diagnostic criteria along with advances in computed tomography imaging technology. We encountered a series of AISs with a peculiar flat cell morphology that were challenging to diagnose using the current diagnostic criteria. Histologically, all 5 tumors showed a lepidic pattern consisting of flat...

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Topics

Humans
Lung Neoplasms
Female
Male
Adenocarcinoma in Situ
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Biomarkers, Tumor

Mutation

Adenocarcinoma

Adenocarcinoma of Lung

Immunohistochemistry

ErbB Receptors

Source

Open in PubMed

Identifiers

PMID: 40865920
DOI: 10.1016/j.modpat.2025.100876

Genes

EGFR
ERBB2

Provenance

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