Article
A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding.
Human mutation - 1 Mar 2012
Wang Weipeng, Sun Jing, Li Fang, Li Rui, Gu Yongping, Liu Cuiping, Yang Peng, Zhu Ming, Chen Lujun, Tian Wenyan, Zhou Huan, Mao Yong, Zhang Liang, Jiang Jingting, Wu Changping, Hua Dong, Chen Weichang, Lu Binfeng, Ju Jingfang, Zhang Xueguang
Abstract excerpt
Inhibitory costimulatory molecule CD274 expresses in various cancers and contributes to cancer immune evasion by inhibiting T cell activation and proliferation, yet the regulatory mechanisms for CD274 overexpression in cancers are poorly understood. In this study, we discovered a novel mechanism of CD274 expression regulated by miR-570. A guanine-to-cytosine mutation at the 3'-UTR of CD274 mRNA led to CD274...
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