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Article

miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition.

Cancer genetics - 1 Sept 2011

Zhang Ziping, Liu Shaoqun, Shi Rongliang, Zhao Guangfa

Abstract excerpt

microRNAs (miRNAs) play an important role in tumorigenesis. However, the mechanisms by which miRNAs regulate gastric cancer metastasis remain poorly understood. In the current study, we defined the target genes and biological functions of miR-27 with a luciferase reporter assay and Western blot analysis. We verified that miR-27 levels were increased in gastric cancer tissues. The overexpression of miR-27 promoted...

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Identifiers

PMID: 22018270
DOI: 10.1016/j.cancergen.2011.07.004

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APC
ZEB1
ZEB2

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