Article
Predicting clopidogrel response using DNA samples linked to an electronic health record.
Clinical pharmacology and therapeutics - 1 Feb 2012
Delaney J T, Ramirez A H, Bowton E, Pulley J M, Basford M A, Schildcrout J S, Shi Y, Zink R, Oetjens M, Xu H, Cleator J H, Jahangir E, Ritchie M D, Masys D R, Roden D M, Crawford D C, Denny J C
Abstract excerpt
Variants in ABCB1 and CYP2C19 have been identified as predictors of cardiac events during clopidogrel therapy initiated after myocardial infarction (MI) or percutaneous coronary intervention (PCI). In addition, PON1 has recently been associated with stent thrombosis. The reported effects of these variants have not yet been replicated in a real-world setting. We used BioVU, the Vanderbilt DNA repository linked to...
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