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Article

Proteasome inhibition alleviates SNARE-dependent neurodegeneration.

Science translational medicine - 15 Aug 2012

Sharma Manu, Burré Jacqueline, Südhof Thomas C

Abstract excerpt

Activation of the proteasomal degradation of misfolded proteins has been proposed as a therapeutic strategy for treating neurodegenerative diseases, but it is unclear whether proteasome dysfunction contributes to neurodegeneration. We tested the role of proteasome activity in neurodegeneration developed by mice lacking cysteine string protein-α (CSPα). Unexpectedly, we found that proteasome inhibitors alleviated...

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Identifiers

PMID: 22896677
DOI: 10.1126/scitranslmed.3004028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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