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Article

Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype.

Leukemia - 1 Aug 2008

Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T

Abstract excerpt

In acute myeloid leukemia (AML) with complex aberrant karyotype, a loss of one TP53 allele is frequently observed. We analyzed the incidence of TP53 mutations and deletions in 107 AML with complex aberrant karyotype. In 50 of 57 cases showing a loss of one TP53 allele, a TP53 mutation was detecte...

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Share to Genes, p53
Share to Histone-Lysine N-Methyltransferase
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Karyotyping

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

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Source

Identifiers

PMID: 18528419
DOI: 10.1038/leu.2008.143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18528419-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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