p53 mutations: gains or losses?

Abstract excerpt

Although the case for p53 as a tumor suppressor gene appears very strong, one should still keep an open eye for the possibility that mutations in p53 do not necessarily imply a mere loss of "suppressor" activity. It is still possible that the presence of a p53 mutation in a tumor contributes, in a dominant positive manner, to tumorigenesis. In other words, certain p53 mutants may well be oncogenic in their own...

Topics

• Amino Acid Sequence
• Animals
• Genes, Tumor Suppressor
• Humans
• Mice
• Molecular Sequence Data
• Mutation
• Oncogenes
• Sequence Homology, Nucleic Acid
• Tumor Suppressor Protein p53