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Article

Evaluating the Prognostic Impact of IDH Mutations in Intrahepatic Cholangiocarcinoma.

JCO precision oncology - 1 Aug 2026

Harvey Rachel N, Gelfer Rebecca, Drill Esther, Balachandran Vinod, D'Angelica Michael, Drebin Jeffrey, Kingham T Peter, Saadat Lily, Soares Kevin, Wei Alice C, Abou-Alfa Ghassan K, Cercek Andrea, Harding James J, O'Reilly Eileen M, Doukas Michail, Homs Marjolein Y V, Groot Koerkamp Bas, Jarnagin William R

Abstract excerpt

PURPOSE: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutations are common in intrahepatic cholangiocarcinoma (ICC), but their prognostic value is unclear. Using a large data set, we assessed their impact in resected and nonresected ICC. METHODS: Adults from two medical centers (MSKCC and Erasmus) with ICC treated with curative-intent resection (resected) or managed nonoperatively (unresectable) who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42550995
DOI: 10.1200/PO-25-01261

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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