Article
Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway.
Oncotarget - 1 Nov 2013
Wu Qiong, Wang Rui, Yang Qingling, Hou Xin, Chen Sulian, Hou Yueyue, Chen Changjie, Yang Yan, Miele Lucio, Sarkar Fazlul H, Chen Yuqing, Wang Zhiwei
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the common malignances in the world and has high mortality in part due to development of acquired drug resistance. Therefore, it is urgent to investigate the molecular mechanism of drug resistance in HCC. To explore the underlying mechanism of drug resistance in HCC, we developed gemcitabine-resistant (GR) HCC cells. We used multiple methods to achieve our goal including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.