A high-frequency mutation in Bacillus subtilis: requirements for the decryptification of the gudB glutamate dehydrogenase gene.

doi:10.1128/JB.06470-11

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Article

A high-frequency mutation in Bacillus subtilis: requirements for the decryptification of the gudB glutamate dehydrogenase gene.

Journal of bacteriology - 1 Mar 2012

Gunka Katrin, Tholen Stefan, Gerwig Jan, Herzberg Christina, Stülke Jörg, Commichau Fabian M

Abstract excerpt

Common laboratory strains of Bacillus subtilis encode two glutamate dehydrogenases: the enzymatically active protein RocG and the cryptic enzyme GudB that is inactive due to a duplication of three amino acids in its active center. The inactivation of the rocG gene results in poor growth of the bacteria on complex media due to the accumulation of toxic intermediates. Therefore, rocG mutants readily acquire...

Topics

Bacillus subtilis
Bacterial Proteins
DNA, Bacterial
Glutamate Dehydrogenase
Mutation
Pseudogenes
Repetitive Sequences, Nucleic Acid
Suppression, Genetic
Transcription Factors
Transcription, Genetic

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Identifiers

PMID: 22178973
DOI: 10.1128/JB.06470-11
PMCID: PMC3294779

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