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Article

Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival.

Histopathology - 1 Dec 2011

Zhao Fung, Siu Michelle K Y, Jiang LiLi, Tam Kar Fai, Ngan Hextan Y S, Le Xiao-Feng, Wong Oscar G W, Wong Esther S Y, Chan Hoi Yan, Cheung Annie N Y

Abstract excerpt

AIMS: Dedicator of cytokinesis I (Dock180) is a novel guanine nucleotide exchange factor for Rho guanosine triphosphates (GTPases) important for cell migration. The aim of this study was to evaluate the role of Dock180 in ovarian carcinogenesis. METHODS AND RESULTS: Using immunohistochemistry, real-time polymerase chain reaction and Western blotting, overexpression of Dock180 RNA and protein was demonstrated in...

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Identifiers

PMID: 22175896
DOI: 10.1111/j.1365-2559.2011.04045.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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