Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane

Abstract excerpt

Red blood cells (RBC) are essential for the survival of aerobic organisms. Mutations in RBC plasma membrane proteins can give rise to a spectrum of diseases characterized by hemolysis, inefficient gas exchange, and anemia. We tested whether emerin (EMD), a nuclear envelope (NE) protein, is also expressed in anuclear cell types to regulate membrane structure and function. We find that emerin is localized to the RBC...

Topics

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• DNA-Binding Proteins
• Gene Expression Regulation
• Lamin Type A
• Lamins
• Membrane Proteins
• Muscular Dystrophy, Emery-Dreifuss
• Mutation
• Nuclear Proteins

Identifiers and source

Literature Corpus work

543090c3-9ef5-56c3-941f-3b62e9c5dfe2

DOI

10.1101/2025.06.06.658339