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Article

Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling.

The Journal of biological chemistry - 3 Feb 2012

Härtel Tobias, Eylert Eva, Schulz Christian, Petruschka Lothar, Gierok Philipp, Grubmüller Stephanie, Lalk Michael, Eisenreich Wolfgang, Hammerschmidt Sven

Abstract excerpt

The metabolism of Streptococcus pneumoniae was studied by isotopologue profiling after bacterial cultivation in chemically defined medium supplemented with [U-(13)C(6)]- or [1,2-(13)C(2)]glucose. GC/MS analysis of protein-derived amino acids showed lack of (13)C label in amino acids that were also essential for pneumococcal growth. Ala, Ser, Asp, and Thr displayed high (13)C enrichments, whereas Phe, Tyr, and Gly...

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Identifiers

PMID: 22167202
DOI: 10.1074/jbc.M111.304311
PMCID: PMC3281726

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