Article
Gender-dependent association of type 2 diabetes with the vasoactive intestinal peptide receptor 1.
Gene - 10 Feb 2012
Paladini Fabiana, Adinolfi Valerio, Cocco Elisa, Ciociola Ester, Tamburrano Giulia, Cascino Isabella, Lucantoni Federica, Morano Susanna, Sorrentino Rosa
Abstract excerpt
Type 2 diabetes is characterized by an inadequate pancreatic beta-cell response to the progressive insulin resistance. Its pathogenesis is complex and has been connected with a state of preclinical chronic inflammation. Vasoactive intestinal peptide (VIP) and its receptors play a relevant role in the homeostasis of insulin secretion as well as in the control of inflammation. In particular, VIP receptor 1 (VPAC1)...
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