Article
The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center.
The Journal of clinical endocrinology and metabolism - 1 Feb 2012
Elisei Rossella, Romei Cristina, Renzini Giulia, Bottici Valeria, Cosci Barbara, Molinaro Eleonora, Agate Laura, Cappagli Virginia, Miccoli Paolo, Berti Piero, Faviana Pinuccia, Ugolini Clara, Basolo Fulvio, Vitti Paolo, Pinchera Aldo
Abstract excerpt
BACKGROUND: Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-producing C-cell tumor. In hereditary cases, a germline RET mutation is found in 98% of families. Because MTC is cured only if intrathyroidal, prophylactic thyroidectomy is recommended in the gene carrier (GC). AIMS: The aim was to determine whether thyroidectomy performed when stimulated CT becomes detectable is as safe as prophylactic...
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