Effects of Ortho‐dihydroxyisoflavone Derivatives from Korean Fermented Soybean Paste on Melanogenesis in B16 Melanoma Cells and Human Skin Equivalents

Abstract excerpt

In this study we investigated the inhibitory effects and possible mechanisms of action of 8'-hydroxydaidzein and 3'-hydroxydaidzein, two ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste, on melanogenesis in B16 murine melanoma cells. The two hydroxydaidzeins reduced melanin synthesis comparably to treatment with kojic acid, a proven whitening agent, in B16 melanoma cells. Furthermore,...

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