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Article

Acetazolamide Inhibits the Level of Tyrosinase and Melanin: An Enzyme Kinetic, In Vitro, In Vivo, and In Silico Studies

29 May 2017

Abstract excerpt

Melanin is the major factor that determines skin color and protects from ultraviolet radiation. In present study we evaluated the anti‐melanogenesis effect of acetazolamide (ACZ) using four different approaches: enzyme kinetic, in vitro, in vivo and in silico. ACZ demonstrated significant inhibitory activity (IC50 7.895 ± 0.24 μm) against tyrosinase as compared to the standard drug kojic acid (IC50 16.84 ± 0.64...

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PMID: 28557244
DOI: 10.1002/cbdv.201700117

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