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The p300 KAT inhibitor, A-485, inhibits melanogenesis and melanin content in human melanocytes

2024-02-16

Abstract excerpt

Hyperpigmentation disorders are commonly diagnosed dermatologic conditions that can be cosmetically distressing for patients and cause negative psychosocial impacts. There is a need to better understand the underlying pathophysiology of pigmentary disorders as well as develop improvements in the management of these disorders. Here, we evaluated a p300 (CBP/p300) histone acetyltransferase (HAT) inhibitor, A-485, to...

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Identifiers and source

Literature Corpus work
05f9c729-3630-5339-b107-ad87f2d0ea63
DOI
10.1101/2024.02.14.580089
Open publication

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