Article
Association of the miR-146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population.
Molecular carcinogenesis - 1 Oct 2012
Min Kyung Tae, Kim Jong Woo, Jeon Young Joo, Jang Moon Ju, Chong So Young, Oh Doyeun, Kim Nam Keun
Abstract excerpt
MicroRNAs (miRNAs) are small, 18- to 22-nucleotide non-coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA...
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