Article
Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2007
Granville Courtney A, Warfel Noel, Tsurutani Junji, Hollander M Christine, Robertson Matthew, Fox Stephen D, Veenstra Timothy D, Issaq Haleem J, Linnoila R Ilona, Dennis Phillip A
Abstract excerpt
PURPOSE: Human and murine preneoplastic lung lesions induced by tobacco exposure are characterized by increased activation of the Akt/mammalian target of rapamycin (mTOR) pathway, suggesting a role for this pathway in lung cancer development. To test this, we did studies with rapamycin, an inhibi...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.