Article
Mendelian randomization: application to cardiovascular disease.
Current hypertension reports - 1 Feb 2012
Timpson Nicholas J, Wade Kaitlin H, Smith George Davey
Abstract excerpt
In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy...
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