Article
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Blood - 9 Feb 2012
Zhao Ling, Melenhorst Jan J, Alemu Lemlem, Kirby Martha, Anderson Stacie, Kench Maggie, Hoogstraten-Miller Shelley, Brinster Lauren, Kamikubo Yasuhiko, Gilliland D Gary, Liu P Paul
Abstract excerpt
KIT mutations are the most common secondary mutations in inv(16) acute myeloid leukemia (AML) patients and are associated with poor prognosis. It is therefore important to verify that KIT mutations cooperate with CBFB-MYH11, the fusion gene generated by inv(16), for leukemogenesis. Here, we transduced wild-type and conditional Cbfb-MYH11 knockin (KI) mouse bone marrow (BM) cells with KIT D816V/Y mutations. KIT...
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