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Article

Prevention of adverse cardiac remodeling to volume overload in female rats is the result of an estrogen-altered mast cell phenotype.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2012

Lu Hong, Meléndez Giselle C, Levick Scott P, Janicki Joseph S

Abstract excerpt

Previously, we have reported sex differences in the cardiac remodeling response to ventricular volume overload whereby male and ovariectomized (OVX) female rats develop eccentric hypertrophy, and intact (Int) female rats develop concentric hypertrophy. In males, this adverse remodeling has been attributed to an initial cascade of events involving myocardial mast cell and matrix metalloproteinase activation and...

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Identifiers

PMID: 22160000
DOI: 10.1152/ajpheart.00980.2011
PMCID: PMC3353795

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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