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Article

-174G/C IL-6 gene promoter polymorphism predicts therapeutic response to TNF-α blockers.

Pharmacogenetics and genomics - 1 Feb 2012

Di Renzo Laura, Bianchi Alessia, Saraceno Rosita, Calabrese Vittorio, Cornelius Caroline, Iacopino Leonardo, Chimenti Sergio, De Lorenzo Antonino

Abstract excerpt

BACKGROUND: Although TNF-α blockade is a very effective therapy for psoriasis, not all patients achieve a favorable outcome. The association between IL-6 and psoriasis has been investigated but no papers have focused on the pharmacogenetics of IL-6. OBJECTIVE: To examine whether the G or the C allele, at position -174 in the promoter of IL-6, influences the relationships between body weight, body composition, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22158445
DOI: 10.1097/FPC.0b013e32834e5e7b

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TNF

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