Article
An equivalence principle for the incorporation of favorable mutations in asexual populations.
Science (New York, N.Y.) - 17 Mar 2006
Hegreness Matthew, Shoresh Noam, Hartl Daniel, Kishony Roy
Abstract excerpt
Rapid evolution of asexual populations, such as that of cancer cells or of microorganisms developing drug resistance, can include the simultaneous spread of distinct beneficial mutations. We demonstrate that evolution in such cases is driven by the fitness effects and appearance times of only a small minority of favorable mutations. The complexity of the mutation-selection process is thereby greatly reduced, and...
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