Defective Neutrophil Function in Patients with Sepsis Is Mostly Restored by ex vivo Ascorbate Incubation

Abstract excerpt

Background: Neutrophil function is essential for effective defence against bacterial infections but is defective in patients with sepsis. Ascorbate or vitamin C, which is low in the plasma of patients with sepsis, is stored inside human neutrophils and is essential for their normal function. Objective: This study aimed to determine if ascorbate treatment ex vivo improved neutrophil function in patients with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Sepsis Diagnosis and Treatment
• Share to Vitamin C and Antioxidants Research