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Article

Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome.

The Journal of clinical investigation - 1 Apr 1999

Jain A, Atkinson T P, Lipsky P E, Slater J E, Nelson D L, Strober W

Abstract excerpt

X-linked hyper-IgM syndrome (XHIM) results from mutations in the gene encoding for CD40 ligand (CD154). Patients with the syndrome suffer from infections with opportunistic pathogens such as Cryptosporidium and Pneumocystis carinii. In this study, we demonstrate that activated T cells from patients with XHIM produce markedly reduced levels of IFN-gamma, fail to induce antigen-presenting cells to synthesize IL-12,...

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Share to Antigen-Presenting Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10207167
DOI: 10.1172/JCI5891
PMCID: PMC408278

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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