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Article

TNF-α genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis.

Liver international : official journal of the International Association for the Study of the Liver - 1 May 2012

Kim Sang-Heon, Kim Sang-Hoon, Yoon Ho Joo, Shin Dong Ho, Park Sung Soo, Kim Youn-Seup, Park Jae-Seuk, Jee Young-Koo

Abstract excerpt

BACKGROUND: While the mechanisms underlying the development of drug-induced liver injury are not clear, there is evidence to suggest that tumor necrosis factor-α (TNF-α) plays an important role in drug- or drug metabolite-induced immune responses. We hypothesized that polymorphisms in the TNF-α gene are associated with anti-tuberculosis drug (ATD)-induced hepatitis. METHODS: Patients who suffered from ATD-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22151084
DOI: 10.1111/j.1478-3231.2011.02697.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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