Article
Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture.
Molecular & cellular proteomics : MCP - 1 Feb 2012
Thomas Louise, Hodgson David A, Wentzel Alexander, Nieselt Kay, Ellingsen Trond E, Moore Jonathan, Morrissey Edward R, Legaie Roxane, Wohlleben Wolfgang, Rodríguez-García Antonio, Martín Juan F, Burroughs Nigel J, Wellington Elizabeth M H, Smith Margaret C M
Abstract excerpt
Bacteria in the genus Streptomyces are soil-dwelling oligotrophs and important producers of secondary metabolites. Previously, we showed that global messenger RNA expression was subject to a series of metabolic and regulatory switches during the lifetime of a fermentor batch culture of Streptomyces coelicolor M145. Here we analyze the proteome from eight time points from the same fermentor culture and, because...
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