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Article

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer.

Gut - 1 Mar 2012

Aghdassi Ali, Sendler Matthias, Guenther Annett, Mayerle Julia, Behn Claas-Olsen, Heidecke Claus-Dieter, Friess Helmut, Büchler Markus, Evert Matthias, Lerch Markus M, Weiss Frank Ulrich

Abstract excerpt

OBJECTIVE: Pancreatic cancer is characterised by invasive tumour spread and early metastasis formation. During epithelial-mesenchymal transition, loss of the cell adhesion molecule E-cadherin is frequent and can be caused by genetic or epigenetic modifications, recruitment of transcriptional activators/repressors or post-translational modifications. A study was undertaken to investigate how E-cadherin expression...

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Source

Identifiers

PMID: 22147512
DOI: 10.1136/gutjnl-2011-300060

Genes

CDH1
ZEB1
HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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