Article
Mechanistic insights into the link between visfatin gene C-1535T polymorphism and coronary artery disease: an in vitro study.
Molecular and cellular biochemistry - 1 Apr 2012
Wang Yong-Sheng, Gao Wei, Li Hong-Fen, Wang Ze-Mu, Zhu Jun, Zhao Huan, Yan Jian-Jun, Jia En-Zhi, Yang Zhi-Jian, Wang Lian-Sheng
Abstract excerpt
Visfatin, a pro-inflammatory cytokine predominantly released from leucocytes, is correlated with coronary artery disease (CAD). We have previously reported that the -1535C>T polymorphism (rs1330082), which located on the promoter region of visfatin, was associated with decreased risk of CAD. Here, we investigated the underlying mechanism by which this polymorphism affects the genetic susceptibility to CAD. The...
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