Article
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocrine journal - 1 Mar 2008
Tokunaga Ayumi, Miura Atsuko, Okauchi Yukiyoshi, Segawa Katsumori, Fukuhara Atsunori, Okita Kohei, Takahashi Masahiko, Funahashi Tohru, Miyagawa Jun-Ichiro, Shimomura Iichiro, Yamagata Kazuya
Abstract excerpt
Visfatin is a novel adipocytokine that is expressed by the visceral fat cells. We investigated the role of genetic variation in the visfatin gene in the pathophysiology of type 2 diabetes and clinical variables in Japanese subjects. The 11 exons, and the promoter region of the visfatin gene were screened for single nucleotide polymorphisms (SNPs) by PCR-direct sequencing. We found SNPs in the promoter region (SNP...
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