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Characteristics of <i>Borrelia hermsii</i> infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever

5 Dec 2011

Abstract excerpt

Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fever (RF) in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans. We...

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PMID: 22143787
DOI: 10.1073/pnas.1108776109

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