A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.

doi:10.1158/1078-0432.CCR-11-1387

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Article

A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2012

Innocenti Federico, Owzar Kouros, Cox Nancy L, Evans Patrick, Kubo Michiaki, Zembutsu Hitoshi, Jiang Chen, Hollis Donna, Mushiroda Taisei, Li Liang, Friedman Paula, Wang Liewei, Glubb Dylan, Hurwitz Herbert, Giacomini Kathleen M, McLeod Howard L, Goldberg Richard M, Schilsky Richard L, Kindler Hedy L, Nakamura Yusuke, Ratain Mark J

Abstract excerpt

BACKGROUND AND AIMS: Cancer and Leukemia Group B 80303 was a randomized, phase III study in patients with advanced pancreatic cancer treated with gemcitabine plus either bevacizumab or placebo. We prospectively collected germline DNA and conducted a genome-wide association study (GWAS) using overall survival (OS) as the endpoint. EXPERIMENTAL DESIGN: DNA from 351 patients was genotyped for more than 550,000...

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PMID: 22142827
DOI: 10.1158/1078-0432.CCR-11-1387
PMCID: PMC3412624

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